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The theory and practice of medicine in Canada changed significantly from the 16th to the 20th century, with important developments in medical education and regulation, understanding of anatomy and disease, public health and immunization, and pharmacology.

The pharmaceutical industry involves companies that research, create, market and sell both generic and brand-name drugs.

 Medical research ranges from fundamental research to clinical and applied technology.

The most damaging pandemic of influenza — for Canada and the world — was an H1N1 virus that appeared during the First World War. Despite its unknown geographic origins, it is commonly called the Spanish flu. In 1918–19, it killed between 20 and 100 million people, including some 50,000 Canadians.

Canada's first highways were the rivers and lakes used by Indigenous peoples, travelling by canoe in summer and following the frozen waterways in winter. (See also Birchbark Canoe; Dugout Canoe.) The water network was so practical that explorers, settlers and soldiers followed the example of the Indigenous peoples. (See also Coureurs des bois; Voyageurs.) To a greater extent than most other countries, Canada depends for its social, economic and political life on efficient communication and transportation. (See also Economy; Politics.)

Iron is the primary raw material used to produce steel — itself an alloy of concentrated iron with a minute amount of carbon.

Ice Age, the Pleistocene epoch of geologic time, during which periodic, extensive glacial activity occurred in many parts of the world.

The Armand-Frappier Santé Biotechnologie Research Centre, is part of the Institut national de la recherche scientifique (INRS). It is an important centre for research, training and technology transfer (see Medical Education).

The energy contained in sunlight is the source of life on Earth. Humans can harness it to generate power for our activities without producing harmful pollutants. There are many methods of converting solar energy into more readily usable forms of energy such as heat or electricity. The technologies we use to convert solar energy have a relatively small impact on the environment. However, they each have disadvantages that have kept them from being widely adopted.

In Canada, the use of solar energy to generate electricity and heat is growing quickly and is helping reduce pollution related to energy production. Despite Canada’s cold climate and high latitudes (which get less direct sunlight than mid-latitudes), solar power technologies are used in many places, from household rooftops to large power plants. The Canada Energy Regulator (formerly the National Energy Board) expects solar power to make up 3 per cent of Canada’s total electricity generation capacity by 2040.

Climate change occurs when long-term weather patterns begin to shift. These periods of change have occurred throughout the Earth’s history over extended periods of time. However, since the Industrial Revolution the world has been warming at an unprecedented rate. Because of this, the current period of climate change is often referred to as “global warming.” Human activities that release heat-trapping greenhouse gases, such as the burning of fossil fuels, are largely responsible for this increased rate of change. The implications of this global increase in temperature are potentially disastrous and include extreme weather events, rising sea levels and loss of habitat for plants, animals and humans. In Canada, efforts to mitigate climate change include phasing-out coal-fired power plants in Ontario and instituting a carbon tax in British Columbia.

(This is the full-length entry about climate change. For a plain-language summary, please see Climate Change (Plain-Language Summary).)

TC Energy Corporation (formerly TransCanada Corporation) is a natural gas, oil and power-generation company headquartered in Calgary, Alberta. TC Energy owns more than 92,600 km of natural gas pipeline in North America and transports more than 25 per cent of the gas consumed on the continent. It also operates power plants and gas storage facilities. A public company, it trades on the Toronto Stock Exchange and the New York Stock Exchange under the symbol TRP. In 2018, TC Energy registered $13.7 billion in revenue and $3.5 billion in profit and held $98.9 billion in assets. The company employs about 7,300 people, more than half of them in Canada.

Keystone XL was a proposed 1,947 km long pipeline project that would have carried crude oil from Alberta to Nebraska. It was owned by Calgary-based TC Energy Corporation. The pipeline was named XL for “export limited.” First proposed in July 2008, it was the prospective fourth phase of TC Energy’s existing Keystone Pipeline system. In Canada, Keystone XL had the support of both the federal and Alberta governments. However, the project faced significant opposition and legal challenges on environmental grounds. In January 2021, United States president Joe Biden cancelled its permit on his first day in office. On 9 June 2021, TC Energy and the Alberta government announced the termination of the Keystone XL pipeline.

Medical ethics are concerned with moral questions raised by the practice of medicine and, more generally, by health care.

Conjugated Estrogens CSD (Canadian Standard Drug) is a female sex hormone complex produced primarily in the ovaries. Many of the female body's vital metabolic and physiologic processes are controlled by estrogen.

One of the fundamental changes to cartography during the 20th century has been the introduction and use of computers and computer-driven machinery (especially drawing and graphic devices) to mapping.